Accession Number : AD0742443

Title :   Mechanisms of Oxygen Toxicity at the Cellular Level.

Descriptive Note : Annual rept. no. 3, 1 Jan-31 Dec 71,

Corporate Author : MISSOURI UNIV COLUMBIA SPACE SCIENCES RESEARCH CENTER

Personal Author(s) : Brown,Olen R.

Report Date : JAN 1972

Pagination or Media Count : 36

Abstract : Over the preceding year, progress has been achieved in several related lines of research which contribute to the contract objective of delineating basic, cellular mechanisms of oxygen toxicity. Each of the following areas has been previously identified with proposals and reports and progress in each area will be reviewed separately. The areas are: (A) Techniques of measuring the toxicity of gaseous environments for cells, (B) Quantification of the oxygen sensitivities of species and strains, (C) oxygen sensitivity of fatty acid synthetase and its components, and the effects of hyperoxia on: (D) pyridine nucleotide coenzymes, (E) oxidative phosphorylation, (F) cellular permeability, (G) respiration, and (H) cellular sulfhydryl. (Author)

Descriptors :   (*OXYGEN, TOXICITY), CELLS(BIOLOGY), SENSITIVITY, FATTY ACIDS, BIOSYNTHESIS, NUCLEOTIDES, COENZYMES, PHOSPHORYLATION, RESPIRATION, PERMEABILITY, THIOLS, MICROORGANISMS, BIOCHEMISTRY, PHYSIOLOGY

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE