Accession Number : AD0742574

Title :   The Crystal Structure of Lidocaine Hydrohexafluoroarsenate,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) BIOCHEMISTRY LAB

Personal Author(s) : Hanson,A. W.

Report Date : 15 JUN 1971

Pagination or Media Count : 8

Abstract : Crystals of lidocaine (2-diethylamino-2', 6'-acetoxylidide) hydrohexafluoroarsenate, C14H23N2OAsF6 are monoclinic, and were observed and measured diffractometrically. The crystal structure was determined by heavy-atom methods and refined by block-diagonal least-squares to a final R index of 0.044. The lidocaine moiety was found to be in the biologically active cationic form, with the amino nitrogen atom protonated. This atom is strongly hydrogen-bonded to the oxygen atom of an adjacent cation. Pairs of such bonds join pairs of cations across centres of symmetry. The amido nitrogen atom is weakly hydrogen-bonded to a fluorine atom of the hexafluoroarsenate anion. (Author)

Descriptors :   (*ARSENIC COMPOUNDS, CRYSTAL STRUCTURE), (*AMIDES, *CRYSTAL STRUCTURE), ANESTHETICS, MOLECULAR ASSOCIATION, AMMONIUM COMPOUNDS, CHEMICAL BONDS, FLUORIDES, SALTS, CANADA

Subject Categories : Pharmacology
      Crystallography
      Atomic and Molecular Physics and Spectroscopy

Distribution Statement : APPROVED FOR PUBLIC RELEASE