Accession Number : AD0742577

Title :   Sporidesmins. Part XII. Isolation and Structure of Sporidesmin G, a Naturally-Occurring 3,6-Epitetrahiopiperazine-2,5-Dione,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA HALIFAX (NOVA SCOTIA) ATLANTIC REGIONAL LAB

Personal Author(s) : Francis,E. ; Rahman,R. ; Safe,S. ; Taylor,A.

Report Date : 16 AUG 1971

Pagination or Media Count : 4

Abstract : When the tail fractions from chromatograms of sporidesmin E (I; n=3) were rechromatographed, a new crystalline metabolite of Pithomyces chartarum was isolated with molecular formula C18H20ClN3O6S4. The new compound, named, sporidesmin G (I; n=4), gave sporidesmin (I; n=2) on irradiation of treatment with triphenylphosphine, and sporidesmin D (V) after reduction and methylation. It was shown that the model compound, 1,4-dimethyl-3,6-epidithiopiperzine-2,5-dione, gave the cyclic tetraulphide on treatment with dihydrogen disulphide. Similarly, sporidesmin and sporidesmin E when treated with dihydrogen disulphide gave the new metabolite. (Author)

Descriptors :   (*FUNGI, *CHROMATOGRAPHIC ANALYSIS), METABOLISM, ORGANIC SULFUR COMPOUNDS, MOLECULAR STRUCTURE, NITROGEN HETEROCYCLIC COMPOUNDS, SYNTHESIS(CHEMISTRY), AMIDES, CANADA

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE