Accession Number : AD0742579

Title :   Sporidesmins. Part XIII. Ovine III-thrift in Nova Scotia. Part III. The Characterisation of Chetomin a Toxic Metabolite of 'Chaetomium cochliodes; and 'Chaetomium globosum',

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA HALIFAX (NOVA SCOTIA) ATLANTIC REGIONAL LAB

Personal Author(s) : Safe,S. ; Taylor,A.

Report Date : 24 AUG 1971

Pagination or Media Count : 9

Abstract : Chetomin, one of the antibiotic metabolites of Chaetomium cochliodes and C. globosium has been isolated as an amorphous, glass-like solid. Elemental analysis of chetomin, its diacetate, and its bistrimethylsilyl ether, mass spectroscopy of its tetrathiomethyl derivative, and n.m.r. spectroscopy indicate the molecular formula to be C31H30N6O6S4. The formation of a tetra-S-methyl derivative and a bismonosulphide indicated the presence of two epidithiodioxopiperazine ring systems like those present in chaetocin, a metabolite of C. minutum, a conclusion supported by the close similarity of the c.d. of the two metabolites. The u.v. spectrum of chetomin was the same as that of echinulin. These facts, and an interpretation of the n.m.r. spectra of chetomin and its derivatives, lead one to believe that the molecule contains an indole, an indoline, and two epidithiodioxopiperazine systems. (Author)

Descriptors :   (*FUNGI, *ANTIBIOTICS), ASCOMYCETES, CHEMICAL ANALYSIS, MOLECULAR WEIGHT, NITROGEN HETEROCYCLIC COMPOUNDS, CANADA

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE