Accession Number : AD0742878

Title :   Ultrastructural, Molecular Cytological and Enzymatic Characteristics of the Red Blood Cell Integument with Special Reference to Damage Produced by Various Chemical and Physical Agents.

Descriptive Note : Final rept.,

Corporate Author : BOSTON UNIV MASS DEPT OF BIOLOGY

Personal Author(s) : Stewart,Gwendolyn J.

Report Date : 1972

Pagination or Media Count : 13

Abstract : The occurrence of low levels of thrombin action in ACD bank blood was indicated by the presence of small clumps of fibrin in electron microscope specimens prepared from blood stored for 5 or more days. The case for investigating the possibility that low level thrombin action is a significant factor in shortening the survival of red cells during storage may be based on: (1) the change of behavior of fresh red cells during the natural activation and action of thrombin; (2) the indication that thrombin cleaves a peptide bond in a membrane-associated protein; (3) the demonstration that low levels of thrombin action occur in ACD bank blood. The demonstration that low levels of thrombin action do occur in stored blood and reduce the mechanical strength of red cells provides a basis for designing studies to incorporate thrombin inhibitors to increase the storage life of bank blood.

Descriptors :   (*ERYTHROCYTES, STORAGE), (*BLOOD, STORAGE), (*THROMBIN, BLOOD), PRESERVATION, DAMAGE, VIABILITY, ENZYMES, CYTOLOGY, MOLECULAR STRUCTURE, PHOSPHORUS COMPOUNDS

Subject Categories : Medical Facilities, Equipment and Supplies

Distribution Statement : APPROVED FOR PUBLIC RELEASE