Accession Number : AD0743536

Title :   Interrelation of Systemic and Cellular Responses to Acute and Chronic Hypoxia.

Descriptive Note : Final rept. 1 Jan 63-31 Dec 70,

Corporate Author : NORTH CAROLINA UNIV CHAPEL HILL

Personal Author(s) : Miller,A. T. , Jr

Report Date : 04 NOV 1971

Pagination or Media Count : 58

Abstract : A number of separate, though interrelated projects are described in this report. They are grouped into two major categories - (1) the effects of hypoxia on cell metabolism, and (2) the effects of hypoxia on behavior. One of the major objectives was a study of certain features of the process of acclimation to simulated high altitude. This included (a) the effects of altitude acclimation on cellular metabolic and behavioral responses to acute hypoxia, (b) the effects of altitude acclimation on one of the enzymes important to anaerobic metabolism (latic dehydrogenase) and on the relative vascularity of brain, heart and skeletal muscle, (c) the adaptive value of two of the prominent changes observed at altitude (hyperventilation and polycythemia), and (d) an attempt to determine the stimulus responsible for the increased vascularity of organs in altitude-acclimated animals. (Author)

Descriptors :   (*HYPOXIA, *CELLS(BIOLOGY)), (*BLOOD CIRCULATION, HYPOXIA), (*HIGH ALTITUDE, ACCLIMATIZATION), METABOLISM, ENZYMES, OXIDOREDUCTASES, LACTIC ACID, BRAIN, HEART, MUSCULOSKELETAL SYSTEM, RESPIRATION, TOLERANCES(PHYSIOLOGY), RATS, REPTILES

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE