Accession Number : AD0743713

Title :   Agonist-Antagonist Interaction at the Cholinergic Receptor of Denervated Diaphragm,

Corporate Author : DEFENCE STANDARDS LABS MARIBYRNONG (AUSTRALIA)

Personal Author(s) : Freeman,Shirley E. ; Turner,R. J.

Report Date : 22 DEC 1971

Pagination or Media Count : 14

Abstract : A study has been made of the cholinergic receptor induced by chronic denervation in the rat diaphragm. The agonists acetylcholine, carbachol and tetramethylammonium produced a dose-dependent contraction of the denervated diaphragm. These agonists also brought about a graded depolarization of the muscle cells. Supramaximally effective doses of agonists caused desensitization of the preparation; however, there was no cross tachyphylaxis between acetylcholine and carbachol. (Author)

Descriptors :   (*PARASYMPATHOLYTIC AGENTS, PHARMACOLOGY), (*PARASYMPATHOMIMETIC AGENTS, PHARMACOLOGY), DIAPHRAGMS(ANATOMY), AUTONOMIC NERVOUS SYSTEM, ACETYLCHOLINE, CARBAMIC ACID, NEUROMUSCULAR TRANSMISSION, INHIBITION, MUSCLE RELAXANTS, DOSAGE

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE