Accession Number : AD0744967
Title : Platelet Aggregation Produced by Collagenolysis Product Peptides,
Corporate Author : CHILDREN'S HOSPITAL WASHINGTON D C BIOCHEMICAL RESEARCH LAB
Personal Author(s) : Houck,J. ; Chang,C.
Report Date : 1972
Pagination or Media Count : 8
Abstract : Saline solutions of about 1 microgram of each of seven of the eight collagen peptides released by the action of cutaneous collagenase upon soluble collagen were capable of affecting the aggregation of platelets. Thus, at least two important cellular responses to injury (i.e., PMN infiltration and platelet aggregation) can be demonstrated to be produced by the products of collagenolysis. These findings on platelet aggregation reinforce the relative importance of collagenolysis product peptides in the overall process of inflammation.
Descriptors : (*COLLAGEN, *BLOOD COAGULATION), HYDROLYSIS, PROTEINS, PEPTIDES, BLOOD PLATELETS, ENZYMES, WOUNDS AND INJURIES, CELLS(BIOLOGY), LEUKOCYTES, RESPONSE(BIOLOGY)
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE