Accession Number : AD0744968

Title :   Protein Chemistry of Necrotic Wounds,

Corporate Author : CHILDREN'S HOSPITAL RESEARCH FOUNDATION WASHINGTON D C

Personal Author(s) : Houck,John C. ; DeAngelis,Richard J.

Report Date : 1972

Pagination or Media Count : 11

Abstract : Acute inflammation involves the initial and characteristic responses of tissues to trauma. They involve (1) the initial increase in the permeability to microcirculation; (b) the accumulation of firstly, polymorphonuclear (PMN) leukocytes and secondly, mononuclear leukocytes in the wound. It has been shown that collagenolysis, which occurs within the wound space during necrosis, releases peptides of relatively small molecular weight which are chemotactic for PMN, but not lymphocytes or mononuclear cells. The objectives of the studies reported are as follows: Continue studies of the chemotactic properties of the breakdown products of cutaneous collagenolysis produced by the activit of isolated and purified cutaneous collagenase; Isolate and characterize the permeability increasing component of lymphocytes; Isolate purify and characterize the migration inhibitory factor (MIF) of macrophages released from lymphocytes; Isolate and purify the macromolecular material contained within the lymphoid tissue which is specific for the inhibition of mitosis within lymphocytes.

Descriptors :   (*PROTEINS, *NECROSIS), TISSUES(BIOLOGY), WOUNDS AND INJURIES, BLOOD CIRCULATION, LEUKOCYTES, BIOCHEMISTRY, COLLAGEN, PEPTIDES, ENZYMES, HYDROLYSIS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE