Accession Number : AD0745112

Title :   Hemoglobin Function in Stored Blood: XII. Effects of Varying Phosphate Concentrations on Red Cell ATP and 2,3-DPG with Adenine and Inosine.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Dawson,R. Ben , Jr. ; Kocholaty,Walter F.

Report Date : 30 MAR 1972

Pagination or Media Count : 10

Abstract : Adenine in a concentration of 2 mM was most effective for maintaining 2,3-DPG and ATP levels under the conditions of the study. When the preservative contained adenine and inosine the highest concentrations of phosphate, 6 mM and 8 mM, maintained both ATP and 2.3-DPG better during the first two weeks; however, during the third week the intermediate concentration of phosphate, 4 mM, seemed to be as good or better than all other preservatives for maintaining 2,3-DPG and ATP. After three weeks of storage there appeared to be little difference between preservatives with respect to maintaining 2,3-DPG although ATP was better maintained in both the adenine and the adenine plus inosine preservatives containing high phosphate concentrations. (Author)

Descriptors :   (*BLOOD, STORAGE), (*HEMOGLOBIN, PHYSIOLOGY), (*ERYTHROCYTES, PHOSPHATES), ADENINE, ADENOSINE PHOSPHATES, EFFICIENCY, BLOOD, PRESERVATION

Subject Categories : Medical Facilities, Equipment and Supplies

Distribution Statement : APPROVED FOR PUBLIC RELEASE