Accession Number : AD0745326

Title :   Sequential Search of an Optimal Dosage, II.

Descriptive Note : Technical rept.,

Corporate Author : CASE WESTERN RESERVE UNIV CLEVELAND OHIO DEPT OF MATHEMATICS AND STATISTICS

Personal Author(s) : Eichhorn,Benjamin H.

Report Date : 15 JUL 1972

Pagination or Media Count : 17

Abstract : Sequential search procedures are described for determining an optimal dosage in the following biomedical problem. People are subjected to a certain chemotheraputic treatment and on the one hand it is desirable to give each individual the maximal possible dosage. On the other hand, high doses create considerable toxicity, and it is undesirable to cross a certain limit of allowable toxicity level. The optimal dosage is defined as the maximal dose for which the proportion of patients in the population whose toxicity level will not cross the allowable limit is gamma. In the present paper the author discusses non-Bayesian sequential search procedures for the optimal dosage, assuming a linear regression between toxicity and dosage, and normal conditional distribution of the toxicity level at each dose. (Author)

Descriptors :   (*DOSAGE, OPTIMIZATION), SEARCH THEORY, SEQUENTIAL ANALYSIS, REGRESSION ANALYSIS, TOXICITY, STOCHASTIC PROCESSES, APPROXIMATION(MATHEMATICS)

Subject Categories : Medicine and Medical Research
      Statistics and Probability

Distribution Statement : APPROVED FOR PUBLIC RELEASE