Accession Number : AD0746244

Title :   The Effect of Drugs upon a Modified Sidman Avoidance Schedule That Employs Response-Independent Shock: A Preliminary Report on Cholinergic Agents.

Descriptive Note : Technical rept. Mar-Jun 70,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Houser,Vincent P.

Report Date : JUL 1972

Pagination or Media Count : 22

Abstract : Two squirrel monkeys were trained to respond in a Sidman avoidance procedure in which a conditioned averersive stimulus (CAS) was presented whenever 20 seconds elapsed without a response. Shock was paired with the CAS 20% of the time. A 3-minute tone followed by unavoidable shock was superimposed upon the above schedule. During the tone, only the CAS (no baseline shock) was allowed to occur. Both animals demonstrated facilitation of response rate during the tone under this schedule. Scopolamine (1.0 mg/kg) led to a decrease in response rate with a consequent increase in baseline shock, as well as a reduction in response facilitation during the tone. The effects of pilocarpine (2.5 mg/kg) administration were equivocal, producing non consistent changes in avoidance behavior. These preliminary results indicate that anticholinergic agents may severly disrupt avoidance behavior under the control of a Sidman schedule and may also interfere with the typical behavioral response to signaled response-independent shock. (Author)

Descriptors :   (*PARASYMPATHOMIMETIC AGENTS, *CONDITIONED RESPONSE), (*PARASYMPATHOLYTIC AGENTS, CONDITIONED RESPONSE), BEHAVIOR, SCOPOLAMINE, AUTONOMIC AGENTS, STIMULATION(PHYSIOLOGY), PSYCHOPHYSIOLOGY, EMOTIONS, NERVOUS SYSTEM, PHARMACOLOGY, MONKEYS, EXPERIMENTAL DATA

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE