Accession Number : AD0746848

Title :   The 'Minimum Cell Volume' Model of Freezing Injury,

Corporate Author : AMERICAN NATIONAL RED CROSS BETHESDA MD BLOOD RESEARCH LAB

Personal Author(s) : Meryman,Harold T.

Report Date : 1972

Pagination or Media Count : 11

Abstract : Studies of the mechanism of freezing injury in living cells have resulted in the development of an hypothesis that freezing injury results from osmotic dehydration and volume reduction of cells as extracellular water is frozen out. Regardless of composition, the loss of approximately 65% of animal cell liquid leads to cell damage, while plant cells show a similar limiting dehydration at about 55%. A discussion is made of the osmotic dehydration process.

Descriptors :   (*WOUNDS AND INJURIES, *FREEZING), (*CELLS(BIOLOGY), DEHYDRATION), OSMOTIC PRESSURE, STRESSES, MEMBRANES(BIOLOGY), VAPOR PRESSURE, STABILIZATION, PROTEINS, THEORY

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE