Accession Number : AD0746979

Title :   Pulmonary Gas Transport and the Regulation of Ventilation at Rest and Exercise.

Descriptive Note : Progress rept. no. 4 (Annual), 1 Jan-31 Dec 71,

Corporate Author : COLORADO UNIV DENVER MEDICAL CENTER

Personal Author(s) : Filley,Giles F.

Report Date : JUN 1972

Pagination or Media Count : 40

Abstract : Patients with pulmonary disease and normal men have been studied experimentally to determine, respectively, the pulmonary abnormalities causing arterial hypoxemia and the mechanisms responsible for the hypoxic drive of man during exercise. Forty-seven cases of fibrotic lung disease were analyzed with the aid of a two-compartment lung model which dealt with O2 and CO2 exchange deficiencies due to wasted ventilation and shunted blood flow. Carbon monoxide data analysis is not yet finished. Hypoxic and hypercapneic drives were measured in 8 subjects at rest and at 3 levels of supine bicycle exercise. Both the respiratory mass spectrometer and the fuel cell O2 analyzer underwent substantial improvements during the year. (Author)

Descriptors :   (*LUNG, EXERCISE(PHYSIOLOGY)), HYPOXIA, BLOOD CIRCULATION, CORRELATION TECHNIQUES, FAILURE, TRANSPORT PROPERTIES, ANATOMICAL MODELS, OXYGEN, CARBON DIOXIDE, PATHOLOGY, VENTILATION, SPECTROMETERS, MATHEMATICAL MODELS

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE