Accession Number : AD0747800

Title :   The Effects of Scopolamine upon Spontaneous Wheel Running,

Corporate Author : TEXAS TECH UNIV LUBBOCK CENTER OF BIOTECHNOLOGY AND HUMAN PERFORMANCE

Personal Author(s) : Sanders,Michael G. ; Wood,W. Gibson ; Carlson,Richard H.

Report Date : 1972

Pagination or Media Count : 8

Abstract : The data presented revealed that the scopolamine injected prairie dogs ran significantly less revolutions than the saline injected or control animals. This indicated that the 0.5 mg/kg injection of scopolamine suppressed spontaneous running in the activity wheel. The decrease in activity seems to be contradictory to Payne and Anderson's (1967) findings, however the higher dosage used by Payne and Anderson could possibly account for these differences. However, these results are consonant with the findings of Bradley and Elkes (1957) and Richard Moore (1971) which suggest that scopolamine acts in a sedative manner on the CNS. The results also indicated that the increase in wheel running seen when scopolamine is paired with intracranial stimulation is not due to an arousal effect of the drug.

Descriptors :   (*SCOPOLAMINE, *PHARMACOLOGY), (*PARASYMPATHOLYTIC AGENTS, SCOPOLAMINE), DOSAGE, ACETYLCHOLINE, BRAIN, PHYSIOLOGY, BEHAVIOR, ELECTROENCEPHALOGRAPHY, PERFORMANCE(HUMAN)

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE