Accession Number : AD0749455

Title :   Uptake and Retention of Adenine Moiety by Stored Human Red Blood Cells.

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : DeVenuto,Frank ; Wilson,Sarah M. ; Shields,Charles E.

Report Date : 30 JUN 1972

Pagination or Media Count : 16

Abstract : The adenine moiety, which is utilized by the red cells for net synthesis of various nucleotides, does not appear to be in a steady-state equilibrium between plasma and erythrocytes. As storage time increases, the equilibrium is shifted towards the red cells and reached a maximum radioactive content at 21 days. After this time a reversal occurs. At the beginning of storage the association of adenine with erythrocytes is not very strong, since the radioactive material can be removed to a great extent by saline extraction. The retention increases with length of storage and attains a maximum value at 21 days. Specific association of the radioactive label has been observed with cell populations of low density (young cells). (Author)

Descriptors :   (*BLOOD, STORAGE), (*ADENINE, *ERYTHROCYTES), PRESERVATION, ADENOSINE PHOSPHATES, BIOCHEMISTRY, STABILITY, BLOOD TRANSFUSION

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE