Accession Number : AD0750313

Title :   The Pre-Clinical Detection of Chemical Mutagens and Their Evaluation as Genetic Health Hazards,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Capizzi,Robert L. ; Papirmeister,Bruno

Report Date : 1972

Pagination or Media Count : 15

Abstract : Chemicals possessing a high degree of mutagenic activity have been used for a number of years as laboratory tools for elucidating basic genetic mechanisms. Recent attention, however, has focused on the potential human genetic health hazard posed by exposure to chemicals. Since a mutation represents a sudden and heritable change in genetic material, the exposure of human populations to mutagenic chemicals might account for certain diseases. It has been shown that certain environmental chemicals, food additives, pesticides, and drugs can be mutagenic, carcinogenic and/or teratogenic in subhuman species and in man. To date there are no standardized tests of chemical mutagenesis which would provide the definitive assessment of a chemical's potential to induce mutations in humans. This paper describes the development of a new host-mediated assay utilizing a mammalian cell indicator that is sensitive, reliable and reasonably easy to perform. The comparative advantages of this system over conventional methodology are discussed.

Descriptors :   (*MUTATIONS, *CHEMICALS), HUMANS, GENETICS, PUBLIC HEALTH, EXPOSURE(PHYSIOLOGY), DETECTION, BIOASSAY, PESTICIDES, DRUGS, AIR POLLUTION, MARKERS

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE