Accession Number : AD0750717

Title :   Selective Reductions via Hydrides.

Descriptive Note : Final rept. 1 Jul 66-30 Jun 72,

Corporate Author : PURDUE RESEARCH FOUNDATION LAFAYETTE IND

Personal Author(s) : Brown,Herbert C.

Report Date : OCT 1972

Pagination or Media Count : 31

Abstract : The syntheses, modifications, and chemistry of sodium borohydride and lithium aluminum hydride have been investigated. Research has made it possible to prepare a wide variety of alkyl substituted borohydrides, LiR3BH. These are the most powerful and highly stereoselective reducing agents now available to organic chemists. These have been used in the total synthesis of prostaglandins. Research has opened up a detailed exploration of chloroboranes. These derivatives react rapidly with olefins to produce dialkylboron chloride in excellent yield. (Author)

Descriptors :   (*HYDRIDES, *OXIDATION REDUCTION REACTIONS), (*BOROHYDRIDES, OXIDATION REDUCTION REACTIONS), (*BORON COMPOUNDS, CHEMICAL REACTIONS), STEREOCHEMISTRY, ALKENES, HALOGENATED HYDROCARBONS, KETONES, ALCOHOLS

Subject Categories : Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE