Accession Number : AD0750790

Title :   Synthesis of Organic Compounds for Malaria Chemotherapeutic Studies.

Descriptive Note : Annual progress rept. no. 7, 1 Aug 71-31 Jul 72,

Corporate Author : MIDWEST RESEARCH INST KANSAS CITY MO

Personal Author(s) : Cheng,C. C. ; Chien,Ping-Lu ; McCaustland,D. J. ; Burton,William H.

Report Date : SEP 1972

Pagination or Media Count : 80

Abstract : The work reported herein consists of investigation in the following areas: Side chain modification study of 9-phenanthrenemethanols, Synthesis of certain aminonaphthalenes (deaza analogs of 6-amino- and 8-aminoquinoline), and Structural modification study of 2-(p-chlorophenyl)-2-(4-piperidyl)tetrahydrofuran. During the present report period, a total of 22 new compounds have been synthesized, characterized, and submitted for antimalarial evaluation. (Author)

Descriptors :   (*ANTIMALARIALS, SYNTHESIS(CHEMISTRY)), MOLECULAR STRUCTURE, PHENANTHRENES, CARBINOLS, HALOGENATED HYDROCARBONS, FLUORINE COMPOUNDS, CHLORINE COMPOUNDS, BROMINE COMPOUNDS, POLYCYCLIC COMPOUNDS, PIPERIDINES, PLASMODIUM, PHARMACOLOGY

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE