Accession Number : AD0751435

Title :   Effects of Methylene Chloride Exposure on the Spontaneous Activity of Mice,

Corporate Author : AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Thomas,Anthony A. ; Pinkerton,Mildred K. ; Warden,James A.

Report Date : DEC 1971

Pagination or Media Count : 6

Abstract : The experiments described were conducted during continuous exposure of mice to methylene chloride (dichloromethane). The group exposed to 5000 ppm methylene chloride was severely affected and by the seventh day 50% of the mice died. The 1000 ppm exposed group survived the entire four weeks and the spontaneous activity findings are presented. Results indicate that there is a definite trend toward lower activity during exposure, and when one compares the first two-week exposure period with the second two-week exposure period, activity seems to be stabilized at a considerably lower level.

Descriptors :   (*HALOGENATED HYDROCARBONS, *TOXICITY), SOLVENTS, MICE, BIOASSAY, EXPOSURE(PHYSIOLOGY), TOXIC TOLERANCES, DOSAGE, PHYSIOLOGY

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE