Accession Number : AD0751443

Title :   Continuous Exposure of Animals to Methylisobutylketone,

Corporate Author : AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Vernot,Edmond H. ; MacEwen,James D. ; Harris,Elliott S.

Report Date : DEC 1971

Pagination or Media Count : 11

Abstract : Continuous exposure of dogs, monkeys, mice, and rats to MIBK for two weeks and all animals except mice for 90 days resulted in measurable adverse effects only in the case of rats. Rat kidney weights and kidney to body weight ratios were significantly elevated after exposure to 410 mg/cu m for two weeks, and kidney and liver organ weights and organ to body weight ratios were elevated after exposure to 820 mg/cu m for two weeks and to 410 mg/cu m for 90 days.

Descriptors :   (*PENTANONES, *TOXICITY), (*SPACECRAFT CABINS, FIRE RESISTANT COATINGS), PATHOLOGY, HISTOLOGY, KIDNEYS, LIVER, GASES, TOXIC TOLERANCES, DOSAGE, LABORATORY ANIMALS, EXPOSURE(PHYSIOLOGY), EXPERIMENTAL DATA, SOLVENTS, PLASTICS

Subject Categories : Toxicology
      Coatings, Colorants and Finishes

Distribution Statement : APPROVED FOR PUBLIC RELEASE