Accession Number : AD0751677

Title :   Endotoxin Shock and Myocardial Ultrastructure: Effects of Digoxin.

Descriptive Note : Technical rept.,

Corporate Author : OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY

Personal Author(s) : Coalson,Jacqueline J. ; Woodruff,H. Kay ; Greenfield,Lazar J. ; Guenter,Clarence A. ; Hinshaw,Lerner B.

Report Date : 24 JUL 1972

Pagination or Media Count : 20

Abstract : Recent studies have revealed that the dog heart fails 5-9 hours after endotoxin injection. Digoxin administered after endotoxin injections has been noted to provide functional protection for the heart. In this study, the effect of 7-9 hours of endotoxin shock on myocardial ultrastructure was manifested primarily by severe mitochondrial edema and disruption and the accumulation of intramitochondrial granules. The ultrastructural mitochondrial appearance proved to be a reliable morphologic lesions was effected by early digoxin treatment. The precise mechanism by which digoxin prevented the cardiac lesion is unknown. (Author)

Descriptors :   (*SHOCK(PATHOLOGY), *HEART), (*CARDIAC GLYCOSIDES, SHOCK(PATHOLOGY)), CHEMOTHERAPY, EDEMA, MITOCHONDRIA, HISTOLOGY, PATHOLOGY, DOGS, EXPERIMENTAL DATA

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE