Accession Number : AD0752191

Title :   Replication of Infectious Viral RNA in Isolated Mitochondria. I. Penetration of Viral RNA into Mitochondria and Its Effect on Mitochondrial Synthesis,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s) : Gaitskhoki,V. S. ; Ershov,F. I. ; Kiselev,O. I. ; Menshikh,L. I. ; Zaitseva,O. V.

Report Date : 1972

Pagination or Media Count : 11

Abstract : It is established that during the incubation of isolated mitochondrias of rat livers with infection RNA of Venezuelan equine encephalomyelitis (VEE), its penetration into mitochondria is noted. Actinomycin D and cell sap stimulated RNA penetration. The distribution of viral RNA in mitochondria subfractions was studied. A considerable content of labelled RNA was detected in fractions of internal membranes and the matrix. In mitochondria infected in this manner, incubation of RNA synthesis was noted, and no marked effect on the synthesis of mitochondria protein was observed. (Author)

Descriptors :   (*VIRUSES, MITOCHONDRIA), (*MITOCHONDRIA, RIBONUCLEIC ACIDS), (*RIBONUCLEIC ACIDS, VIRUSES), (*VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS, RIBONUCLEIC ACIDS), ARBOVIRUSES, BIOSYNTHESIS, PROTEINS, CELLS(BIOLOGY), USSR

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE