Accession Number : AD0753051

Title :   Regulation of Corticosteroid Synthesis and Secretion.

Descriptive Note : Final technical rept. 1 Oct 55-30 Sep 72,

Corporate Author : CALIFORNIA UNIV LOS ANGELES CENTER FOR HEALTH SCIENCES

Personal Author(s) : Roberts,Sidney

Report Date : NOV 1972

Pagination or Media Count : 11

Abstract : The research has been directed toward two major problems: (a) localization and control of neurohumoral pathways in the brain which regulate pituitary release of ACTH and (b) the physiological mechanisms and biochemical factors involved in the control of adrenal steroid production. Of particular interest was the finding that slow (modulatory) and rapid (stress-induced) elevations in plasma corticosteroid levels may activate separate central mechanisms, possibly as a result of variations in thresholds to the activating stimuli. In addition, a scheme for a proposed interrelationship of the factors involved in the regulations of adrenocortical steroidogenesis is presented. (Author)

Descriptors :   (*CORTICOSTEROID AGENTS, BIOSYNTHESIS), SECRETION, BRAIN, PHYSIOLOGY, BIOCHEMISTRY, ADRENAL GLANDS, PITUITARY GLAND, STRESS(PSYCHOLOGY), STEROIDS

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE