Accession Number : AD0755162

Title :   Sequential Search of an Optimal Dosage for Cases of Linear Dosage - Toxicity Regression.

Descriptive Note : Technical rept.,

Corporate Author : CASE WESTERN RESERVE UNIV CLEVELAND OHIO DEPT OF MATHEMATICS AND STATISTICS

Personal Author(s) : Eichhorn,Benjamin H.

Report Date : 01 DEC 1972

Pagination or Media Count : 14

Abstract : The problem of determining the optimal dosage is studied for the case of normal distribution of toxicity, with a linear dosage- toxicity relationship. Both the slope and the intercept of the regression line are unknown. A sequential search procedure is derived which is feasible and strongly consistent. A numerical illustration through simulation is given at the end. (Author)

Descriptors :   (*TOXIC TOLERANCES, *SEQUENTIAL ANALYSIS), (*DOSAGE, *TOXICITY), PERMISSIBLE DOSAGE, THRESHOLDS(PHYSIOLOGY), REGRESSION ANALYSIS, STATISTICAL ANALYSIS, MATHEMATICAL MODELS

Subject Categories : Toxicology
      Statistics and Probability

Distribution Statement : APPROVED FOR PUBLIC RELEASE