Accession Number : AD0755162
Title : Sequential Search of an Optimal Dosage for Cases of Linear Dosage - Toxicity Regression.
Descriptive Note : Technical rept.,
Corporate Author : CASE WESTERN RESERVE UNIV CLEVELAND OHIO DEPT OF MATHEMATICS AND STATISTICS
Personal Author(s) : Eichhorn,Benjamin H.
Report Date : 01 DEC 1972
Pagination or Media Count : 14
Abstract : The problem of determining the optimal dosage is studied for the case of normal distribution of toxicity, with a linear dosage- toxicity relationship. Both the slope and the intercept of the regression line are unknown. A sequential search procedure is derived which is feasible and strongly consistent. A numerical illustration through simulation is given at the end. (Author)
Descriptors : (*TOXIC TOLERANCES, *SEQUENTIAL ANALYSIS), (*DOSAGE, *TOXICITY), PERMISSIBLE DOSAGE, THRESHOLDS(PHYSIOLOGY), REGRESSION ANALYSIS, STATISTICAL ANALYSIS, MATHEMATICAL MODELS
Subject Categories : Toxicology
Statistics and Probability
Distribution Statement : APPROVED FOR PUBLIC RELEASE