Accession Number : AD0755240

Title :   Prevention of Pulmonary Oxygen Toxicity: Conclusions.

Descriptive Note : Final rept.,

Corporate Author : SAINT VINCENT'S HOSPITAL AND MEDICAL CENTER OF NEW YORK N Y DEPT OF PATHOLOGY

Personal Author(s) : Paegle,R. D.

Report Date : 31 OCT 1972

Pagination or Media Count : 22

Abstract : Two different methods were tested in order to diminish the effects of oxygen toxicity on experimental animals. First: Rats received various antioxidants separately or in mixtures. Their efficacy in preventing or modifying the morbidity and mortality in an atmosphere of 100% oxygen was determined. The antioxidants, vitamin E, ascorbic acid, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) decreased the mortality of choline deficient rats. Second: The possibility of abolishing sensitivity to pure oxygen by gradual adaptation was explored. Animals exposed to pure oxygen died within 65 hours while rats adapted to 85% O2 for 5-7 days showed increased tolerance to pure oxygen. Adapted animals survived for 7 days with some deaths by 20 days. The O2 concentration during the adaption period and it's duration was varied in this study in order to determine the mix at which at least 90% of the rats will survive 'indefinitely' (arbitrarily defined as 30 days). The extent of fibrosis and other chronic morphologic changes producted by varied forms of adaptation was also compared.

Descriptors :   (*OXYGEN, TOXICITY), THERAPY, RESPIRATION, CARDIOVASCULAR SYSTEM, ANTIOXIDANTS, ADAPTATION(PHYSIOLOGY), SENSITIVITY, TOLERANCES(PHYSIOLOGY), EXPERIMENTAL DATA, RATS

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE