Accession Number : AD0755518

Title :   Primary Irritation Evaluation Program, Study Numbers 51-015-73, 51-017-73, 51-019-73, and 51-020-73.

Descriptive Note : Final rept.,

Corporate Author : ARMY ENVIRONMENTAL HYGIENE AGENCY EDGEWOOD ARSENAL MD

Personal Author(s) : Stine,Rudy

Report Date : DEC 1972

Pagination or Media Count : 7

Abstract : Four candidate repellents were evaluated on New Zealand white rabbits for their potential to cause skin irritation. The data obtained serve as a basis for making recommendations that are intended only for guidance in further entomological testing of the compounds. These recommendations do not constitute approval for testing on human volunteers. The repellents, 1-hexanoyl-4-pipecoline, 1-octanoyl-4-pipecoline, 1-hexanoyl-2-ethylpiperidine, 1-heptanoyl-2-ethylpiperidine (ENT-35633-Ga, ENT-35635-Ga, ENT-35643-Ga and ENT-35644-Ga) produced moderate primary irritation of the intact skin and the skin surrounding an abrasion. These compounds should not be used directly on the skin without a prophetic patch test having been conducted.

Descriptors :   (*INSECT REPELLENTS, *TOXICITY), BIOASSAY, RABBITS, IRRITATING AGENTS, SKIN(ANATOMY), EYE, HUMANS, PIPERIDINES, KETONES, NITROGEN HETEROCYCLIC COMPOUNDS

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE