Accession Number : AD0755705

Title :   Effects of Mannitol and Dextran on Interstitial Pulmonary Edema.

Descriptive Note : Technical rept.,

Corporate Author : OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY

Personal Author(s) : Reif,Michael E. ; McCurdy,James R. ; Coalson,Jacqueline J. ; Greenfield,Lazar J.

Report Date : 12 FEB 1973

Pagination or Media Count : 17

Abstract : Pulmonary interstitial edema in the isogravimetric perfused canine lung produced by venous constriction results in decreased compliance and pulmonary venous PO2, and increased pulmonary capillary pressure. Released of venous constriction is associated with further deterioration in pulmonary venous PO2, and no improvement in lung weight or compliance although PCi returns towards normal. Addition of 15 gms LMS dextran minimizes the fall in PVO2 and shows less perivascular edema microscopically, but does not otherwise differ from untreated controls. In contrast, deleterious effects are noted following addition of 1.5 gms mannitol shown by marked weight gain, increased PCi, decreased PVO2 and decreased compliance. In addition, electron microscopy shows focal endothelial cell damage and more marked perivascular space edema. The adverse effects of mannitol may relate to its smaller molecular weight facilitating entry into the interstitial space. (Author)

Descriptors :   (*RESPIRATORY SYSTEM, *EDEMA), (*DEXTRAN, RESPIRATORY DISEASES), CARBOHYDRATES, ALCOHOLS, OXYGEN CONSUMPTION, THERAPY

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE