Accession Number : AD0755708

Title :   The Plasma Kallikrein-Kinin System in Non-Mammalian Blood: Evolutionary Aspects.

Descriptive Note : Technical rept.,

Corporate Author : OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY

Personal Author(s) : Erdoes,Ervin G. ; Seki,T. ; Miwa,I. ; Nakajima,T.

Report Date : 12 FEB 1973

Pagination or Media Count : 30

Abstract : Presented are studies on four components of the plasma kallikrein-kinin system in blood of vertebrates ranging from mammalian to piscine: (1) prekallikrein activator (factor XII or Hageman factor); (2) kallikrein; (3) kininogen; and, (4) kininase. Activation of a prekallikrein activator released a plasma kinin in plasma of mammals, alligator and turtle. Plasma of snake, frog and fish contained only kininase. Avian plasma had no prekallikrein activator, but all other three factors were present. However, a prekallikrein activator was transferred from mammalian or alligator plasma in avian plasma where it triggered release of a kinin. As stable prekallikrein activator we used an active, adsorbed factor XII preparation after crosslinking it with glutaraldehyde. Acidified avian plasma also released a kinin. The kinins found in bird or alligator plasma acted similar to bradykinin in bio-assays. In isotope dilution studies an avian kinin was indistinguishable from synthetic, labeled bradykinin. We hypothesize that during evolution birds lost one component of the kallikrein-kinin system and the missing prekallikrein activator can be transferred from mammals or loricates into avian plasma. (Author)

Descriptors :   (*HORMONES, ANIMALS), (*REPTILES, HORMONES), (*BIRDS, HORMONES), (*FISHES, HORMONES), BLOOD PROTEINS, BLOOD PLASMA

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE