Accession Number : AD0755726

Title :   Pharmacologic Actions of Histamine and Tripelennamine in Guinea Pigs Exposed to Hyperbaric Helium.

Descriptive Note : Medical research progress rept. no. 4,

Corporate Author : NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s) : Small,Alfred ; McElroy,Howard E. ; Ide,Robert S.

Report Date : JAN 1973

Pagination or Media Count : 27

Abstract : Results of earlier studies indicated that hyperbaric helium had little effect on histamine toxicity, but did reduce the toxicity of tripelennamine in guinea pigs. For this reason, it was of interest to determine whether the antihistaminic action of tripelennamine was similarly affected by hyperbaric helium. Moreover, since antihistamine action was evaluated by measuring the inhibition of response to a standard dose of histamine, the possible effect of hyperbaric helium on the pharmacologic action of histamine was also investigated. (Author)

Descriptors :   (*HISTAMINE, *PHARMACOLOGY), (*ANTIHISTAMINICS, PHARMACOLOGY), (*HELIUM, HISTAMINE), (*HIGH PRESSURE, HISTAMINE), STRESS(PHYSIOLOGY), TOXICITY, GUINEA PIGS, EXPERIMENTAL DATA

Subject Categories : Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE