Accession Number : AD0757154

Title :   Studies of Spontaneous Recovery of Central Respiratory Function after Acetylcholinesterase Inhibition by Organophosphates.

Descriptive Note : Technical rept. Jan 71-Jan 72,

Corporate Author : EDGEWOOD ARSENAL MD

Personal Author(s) : Adams,George K. ; O'Leary,John F. ; Yamamura,Henry I.

Report Date : JAN 1973

Pagination or Media Count : 37

Abstract : Spontaneous recovery of the central respiratory function was studied in anesthetized guinea pigs intoxicated with either pinacolyl methylphosphonofluoridate (Soman) or isopropyl methylphosphonofluoridate (Sarin). The animals were pretreated with atropine methylnitrate to protect muscarinic sites outside of the central nervous system. The intravenous administration of either Soman (38 micro g/kg) or Sarin (80 micro g/kg) produced an immediate disruption of phrenic nerve activity and resulting ventilatory failure. Animals were maintained on artificial respiration until spontaneous functional recovery was complete, as evidenced by the reestablishment of the synchronized burst of activity in the phrenic nerve and the return to tracheal airflow. This usually occurred within 1 hour. To determine whether the spontaneous recovery of respiration and the return of brainstem acetylcholinesterase (AChE) activity could be correlated, animals were sacrificed at predetermined intervals after intoxication, and the brainstem homogenates were analyzed for AChE activity. Results showed no significant return of AChE activity after 1 hour, although functional recovery of respiration was complete within this time. (Author Modified Abstract)

Descriptors :   (*ORGANIC PHOSPHORUS COMPOUNDS, *TOXICITY), (*RESPIRATORY SYSTEM, ORGANIC PHOSPHORUS COMPOUNDS), (*GB AGENT, RESPIRATORY SYSTEM), (*GD AGENT, RESPIRATORY SYSTEM), RECOVERY, RESPIRATION, ACETYLCHOLINESTERASE, PARALYSIS, NERVOUS SYSTEM, CHEMICAL WARFARE AGENTS

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE