Accession Number : AD0758957

Title :   Effect of Hydrochlorothiazide on +Gz Tolerance in Normotensives.

Descriptive Note : Research paper,

Corporate Author : DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)

Personal Author(s) : Pfaff,J. R. ; Newberry,P. D.

Report Date : 1972

Pagination or Media Count : 5

Abstract : Following an episode of incapacitating tetany in a pilot on diuretic therapy for hypertension, an investigation was made on the effect of Hydro-diuril on tolerance to flight stresses. Six healthy, normotensive males were given a familiarization G-tolerance test to grey-out (GTTG) on the human accelerator, followed by a control GTTG and a four-minute exposure to +2.5 Gz during which heart rate, blood pressure, and forearm blood flow were recorded (BP and Q at +2.5 Gz). They were then given 50 mg of Hydro-diuril twice daily, and the GTTG, BP, and Q at +2.5 Gz were repeated after 2 and 4 weeks on the drug. It is concluded that tolerance to + Gz acceleration is reduced by Hydro-diuril in normotensive adult male subjects. Since this drug is used to treat some active aircrew, it is urgent that its effect on G-tolerance be determined in hypertensives. (Author Modified Abstract)

Descriptors :   (*DIURETICS, ACCELERATION TOLERANCE), (*ACCELERATION TOLERANCE, HYPERTENSION), (*HYPERTENSION, DIURETICS), CHEMOTHERAPEUTIC AGENTS, BLOOD PRESSURE, STRESS(PHYSIOLOGY)

Subject Categories : Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE