Accession Number : AD0762026

Title :   Metabolism of the Prostaglandin El in the Cerebral Cortex and Cerebellum of the Dog and Rat.

Descriptive Note : Technical rept.,

Corporate Author : OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY

Personal Author(s) : Nakano,Jiro ; Prancan,Arthur V. ; Moore,Sherry E.

Report Date : 02 MAR 1973

Pagination or Media Count : 12

Abstract : It has been shown that the enzymatic activity of 15-hydroxy-prostaglandin dehydrogenase is very high in the lung, kidney, testicle and placenta, and is low in the plasma, heart, uterus and ovary. Presently, the significance of the uneven distribution of 15-hydroxy-prostaglandin dehydrogenase is a moot question. It is tempting to speculate that the velocity of the inactivation of released prostaglandins may be commensurate with the physiological roles of prostaglandins in particular tissues. It is well established that the prostaglandins given intravenously are inactivated very effectively by the enzyme in the lungs during even a single circulation. It can be conceived that a given amount of released prostaglandins in the central nervous system may exert their actions much longer than that of the intravenously administered prostaglandin in the system since the enzymatic activity is markedly lower in the CNS than the activity in the lungs and kidney. (Author)

Descriptors :   (*HORMONES, *CENTRAL NERVOUS SYSTEM), BRAIN, CEREBRAL CORTEX, CEREBELLUM, OXIDOREDUCTASES, ENZYMES, METABOLISM, PHYSIOLOGY, BIOCHEMISTRY, CARBOXYLIC ACIDS

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE