Accession Number : AD0762336

Title :   Intrarenal Regulating Mechanisms for Renal Hemodynamics during Shock.

Descriptive Note : Final technical rept.,

Corporate Author : MUNICH UNIV (WEST GERMANY) PHYSIOLOGISCHES INSTITUT

Personal Author(s) : Thurau,Klaus

Report Date : FEB 1973

Pagination or Media Count : 24

Abstract : A method was developed which allows the quantitative measurement of renin activity in single juxtaglomerular apparatuses (JGA) of the rat kidney. For this purpose a highly purified rat renin substrate was produced and characterized. This method was applied in order to study the changes in JGA renin activity which occur during acute renal failure induced by temporary renal ischemia. The reduction in glomerular filtration rate in the damaged kidneys was associated with a higher JGA renin activity as compared to that of the normal kidney. Together with the finding that Na concentration in the tubular fluid in the macula densa segment of the nephron is elevated in the damaged kidney, these data are consistent with the operation of a feedback control of GFR. These data implicate new methods of treating acute renal failure. (Author)

Descriptors :   (*KIDNEY FUNCTION TESTS, *SHOCK(PATHOLOGY)), (*BLOOD CIRCULATION, KIDNEYS), PHYSIOLOGY, PATHOLOGY, WEST GERMANY

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE