Accession Number : AD0763394

Title :   The Bohr Effect in Chronic Hypercapnia.

Descriptive Note : Medical research progress rept. no. 3,

Corporate Author : NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CONN

Personal Author(s) : Messier,Arthur A. ; Schaefer,Karl E.

Report Date : 13 DEC 1972

Pagination or Media Count : 16

Abstract : The study investigates whether the changes in oxygen affinity produced by exposure to 15% CO2, which affects oxygen transport by reducing oxygen delivery at the tissue level, would be compensated by changes in the Bohr effect. The Bohr effect showed a marked increase during chronic exposure to 15% CO2. The effective Bohr effect, which is the additional oxygen released at 50% oxyhemoglobin saturation (P50) when blood is acidified from pH 7.4 to 7.3, was found to be elevated during the periods of greatest respiratory stress. These findings are of interest to personnel concerned with toxicological aspects of increased carbon dioxide exposure as potentially found in Navy submarine and diving environments as well as other hazards which might induce an acidosis such as hyperbaric hyperoxia.

Descriptors :   (*CARBON DIOXIDE, TOXICITY), (*OXYGEN, TRANSPORT PROPERTIES), RESPIRATORY SYSTEM, OXYGEN CONSUMPTION, ACIDOSIS, HEMOGLOBIN, DIVING, SUBMARINE PERSONNEL

Subject Categories : Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE