Accession Number : AD0763614

Title :   The Influence of Age and Sex on the Metabolism of Americium by Rats,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGICAL SCIENCES

Personal Author(s) : Durakovic,A. B. ; Hollins,J. G. ; Storr,M. C.

Report Date : 04 OCT 1972

Pagination or Media Count : 7

Abstract : The retention of 241Am by the whole body and tissues has been studied in male and female rats of four ages after intravenous injection of americium in the form of citrate. Significant variations of the metabolism of americium with age and sex have been demonstrated in kidney, liver, and bone. The concentration of americium by kidney and liver was positively correlated with age, while the concentration by bone was negatively correlated with age. The concentration of americium by kidney and bone was greater in male than in female rats, but the concentration by liver was greater in the female rats. The radiotoxicological implications of these results are discussed. (Author)

Descriptors :   (*RADIOACTIVE ISOTOPES, RADIATION EFFECTS), (*RADIATION EFFECTS, *AMERICIUM), METABOLISM, KIDNEYS, LIVER, BONES, MEDICAL RESEARCH, TOXICITY, RATS

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE