Accession Number : AD0763942

Title :   Cytochemistry of Malaria under Treatment.

Descriptive Note : Annual rept. no. 4,

Corporate Author : CASE WESTERN RESERVE UNIV CLEVELAND OHIO INST OF PATHOLOGY

Personal Author(s) : Aikawa,Masamichi

Report Date : 01 AUG 1973

Pagination or Media Count : 48

Abstract : Morphologic and cytochemical surface characteristics of isolated malaria parasites (Plasmodium berghei) and host erythrocytes were compared electron microscopically. Erythrocytes had uniform, finely granular surfaces. Free-parasites exhibited a variety of sizes, shapes, and surface textures. Results of cytochemical analyses using a sialophilic colloidal iron stain indicate that the surface of isolated malaria parasites lack exposed sialic acid groups which normally give rise to a net negative surface charge common to most mammalian cells. Lipoidal plaques at the surfaces of bounding plasma membranes were localized by lipophilic-iron colloid staining. The distribution of lipid plaques, revealed by bound colloid, at the surface of parasites and red cells were similar. However, surfaces of malaria parasites were more intensely stained with patchwork patterns of bound lipophilic colloid more closely knit than those exhibited by erythrocytes. (Modified author abstract)

Descriptors :   (*PLASMODIUM, *CYTOCHEMISTRY), CYTOLOGY, NUCLEI(BIOLOGY), MITOSIS, ELECTRON MICROSCOPY, ANTIMALARIALS, PARASITES, PARASITIC DISEASES, ERYTHROCYTES, LIFE CYCLES

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE