Accession Number : AD0765471

Title :   Hemoglobin Function in Stored Blood: XIII. A Citrate-Adenine Preservative with Optimal pH to Maintain Red Cell 2,3-DPG (Function) and ATP (Viability).

Descriptive Note : Interim rept.,

Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s) : Dawson,R. Ben ; Kocholaty,Walter F. ; Camp,Frank R. , Jr

Report Date : 19 APR 1973

Pagination or Media Count : 15

Abstract : Increasing the pH by a 0.5 increment over the commonly used preservative, acid-citrate-dextrose (ACD), results in a significant improvement in 2,3-DPG, with no significant loss in concentrations of ATP. The intermediate pH preservative, 6.0, also had 2,3-DPG concentrations which equalled those of the low pH preservatives from the 21st to 42nd day. A citrate-adenine preservative, with a pH between 5.5 and 6.0, would seem to be optimal for maintenance of hemoglobin function and red cell viability. (Author)

Descriptors :   (*BLOOD, STORAGE), (*HEMOGLOBIN, PHYSIOLOGY), (*ERYTHROCYTES, *PHOSPHATES), ADENOSINE PHOSPHATES, EFFICIENCY, PRESERVATION, CITRATES, PH FACTOR

Subject Categories : Medical Facilities, Equipment and Supplies

Distribution Statement : APPROVED FOR PUBLIC RELEASE