Accession Number : AD0765929

Title :   The Effects of Washing, EDTA, Magnesium and Calcium on Oxidative Phosphorylation and Respiratory Rates of Mitochondria from Heat- and Cold-Acclimated Rats.

Descriptive Note : Research rept.,

Corporate Author : DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)

Personal Author(s) : McBurney,Linda J. ; Radomski,M. W.

Report Date : 29 AUG 1972

Pagination or Media Count : 16

Abstract : The ADP/O ratios of single-sedimented liver mitochondria from heat-acclimated Sprague-Dawley rats were greater than control and cold-acclimated ratios (heat>control>cold). These differences were abolished by washing the mitochondria. EDTA in the homogenate reduced to a greater extent the magnesium and calcium content in mitochondria of cold- than heat-acclimated preparations. Elevation of magnesium in the medium increased ADP/O values and reduced respiratory rates in all mitochondrial populations. During calcium respiration ADP/O ratios were decreased significantly in cold-acclimated mitochondria. (Author)

Descriptors :   (*PHOSPHORYLATION, TEMPERATURE), (*RESPIRATION, TEMPERATURE), (*ACCLIMATIZATION, TEMPERATURE), MITOCHONDRIA, HEAT, LOW TEMPERATURE, MAGNESIUM, CALCIUM, ETHYLENEDINITRILO TETRAACETATES, ADENOSINE PHOSPHATES, RATS, EXPERIMENTAL DATA, CANADA

Subject Categories : Biochemistry
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE