Accession Number : AD0766504

Title :   The Application of Pattern Recognition to Screening Prospective Anti-Cancer Drugs: Adenocarcinoma 775 Biological Activity Test.

Descriptive Note : Technical rept. no. 1, Apr-Sep 73,

Corporate Author : COLORADO STATE UNIV FORT COLLINS DEPT OF CHEMISTRY

Personal Author(s) : Kowalski,Bruce R. ; Bender,Charles F.

Report Date : SEP 1973

Pagination or Media Count : 14

Abstract : A novel application of pattern recognition to the screening of potential anti-cancer drugs is presented. Structural features of 200 drugs previously tested by the National Cancer Institute for activity in the solid tumor adenocarcinoma 755 screening test are input to a master program of pattern recognition methods. The programs were 93.5% accurate in discriminating drugs with positive anti-neoplastic activity versus those with no anti-cancer activity. Extensions to a more rational approach to 'drug design' are also discussed. (Author)

Descriptors :   (*CHEMOTHERAPEUTIC AGENTS, CANCER), (*CANCER, *DRUGS), (*PATTERN RECOGNITION, DRUGS), PHARMACOLOGY, CHEMISTRY

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE