Accession Number : AD0766958

Title :   A Study of Differences in the Response of Germ-Free and Conventional Rats to Various Centrally Acting Drugs.

Descriptive Note : Progress rept. no. 1 (Final), 1 Jul 71-30 Jun 73,

Corporate Author : HOWARD UNIV WASHINGTON D C COLL OF MEDICINE

Personal Author(s) : Herman,Eugene H. ; Pradhan,S. N.

Report Date : 30 JUN 1973

Pagination or Media Count : 6

Abstract : The effects of certain central nervous system stimulants and depressants were investigated in the germ-free and conventional Sprague-Dawley rats. Less number of germ-free rats showed convulsions and lethal toxicity at 1, 1.5 and 2 mg/kg doses of strychnine and 40, 60 and 80 mg/kg doses of pentylenetetrazol. They also appeared to sleep longer than the conventional rats under 40 mg/kg of pentobarbital. These results thus indicate a trend in the difference in the susceptibility of the germ-free and conventional rats to these neurotropic drugs. (Author)

Descriptors :   (*CNS DEPRESSANTS, GERM FREE ANIMALS), (*CNS STIMULANTS, GERM FREE ANIMALS), (*GERM FREE ANIMALS, DRUGS), TOXICITY, CONVULSIVE DISORDERS, BARBITURATES, RATS, BIOASSAY, PHARMACOLOGY

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE