Accession Number : AD0768809

Title :   Ueber die Wirkung von Nystatin Gegen Candida Albicans im Proteolyse-Kulurfiltrat von Candida Albicans (About the Effect of Nystatin on Candida Albicans in the Proteolysis-Culturefiltrate of C. Albicans),

Corporate Author : ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)

Personal Author(s) : Staib,F. ; Gruehn,G.

Report Date : 02 JUL 1971

Pagination or Media Count : 5

Abstract : The effect of nystatin against 30 strains of C. albicans has been tested in SABOURAUD's glucose broth as well as in the proteolysis-culturefiltrate of C. albicans, strain CBS 2730. Nystatin caused a stronger inhibition in proteolysis-culturefiltrate, having an initial pH of 6,0 than in SABOURAUD's glucose broth. The minimum inhibitory concentration of nystatin in proteolysis-culturefiltrate (initial pH 3,5) was 100 units/ml for 15 strains and exceeding 100 units/ml for 5 strains. In SABOURAUD's glucose broth having the same initial pH, on the other hand, the minimum inhibitory concentration of nystatin was 25 units/ml for 17 strains and 12,5 units/ml for 12 strains. These results are of interest because optimal proteolysis by C. albicans in vitro occurs at a pH of approx. 3,5.

Descriptors :   (*CANDIDA, *FUNGICIDES), CULTURE MEDIA, GROWTH(PHYSIOLOGY), PEPTIDE HYDROLASES, FUNGI, WEST GERMANY

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE