Accession Number : AD0768864

Title :   Role of Mycoplasma Membranes in the Pathogenesis of Primary Atypical Pneumonia.

Descriptive Note : Annual rept. no. 1, 1 Sep 72-31 Aug 73,

Corporate Author : ILLINOIS UNIV URBANA DEPT OF MICROBIOLOGY

Personal Author(s) : Gabridge,Michael G.

Report Date : OCT 1973

Pagination or Media Count : 37

Abstract : Primary atypical pneumonia, caused by Mycoplasma pneumoniae, is a significant health problem among military recruits. The current study was designed to yield information on the mechanism of pathogenesis in this disease. Special processes for the cultivation of the causative agent have been developed. Organisms were collected and membrane fractions were prepared. When membranes were evaluated for cytotoxic potential in the hamster tracheal ring/organ culture system, they displayed active biological activity. The necrosis induced in the ciliated respiratory epithelium was grossly equivalent to that induced by viable cells, and was dose-dependent. The data indicate that the cell membrane of this pathogen may be the site of the toxic factor. Further biological and biochemical identification of this toxic factor could ultimately play a key role in the development of a suitable vaccine to reduce the high morbidity rate associated with this disease. (Author) Portions of this document are not fully legible.

Descriptors :   (*MYCOPLASMA, RESPIRATORY DISEASES), (*RESPIRATORY DISEASES, PATHOLOGY), (*MEMBRANES(BIOLOGY), MYCOPLASMA), RESPIRATORY SYSTEM, CELLS(BIOLOGY), NECROSIS, TOXICITY

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE