Accession Number : AD0768934

Title :   Experimente ueber den Einflussee von Metaboliten und Antimetaboliten am Modell von Trichomonas Vaginalis. VII. Mitteilung: Experimente mit Antimetaboliten (Experiments on the Influence of Metabolites and Antimetabolites on the Model of Trichomonas Vaginalis. VII. Communication: Experiments on Antimetabolites),

Corporate Author : ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)

Personal Author(s) : Christow,Chr. Petrow

Report Date : 30 SEP 1970

Pagination or Media Count : 9

Abstract : Antivitamin testing took place in vitro since in this manner all factors may be better considered in experiment. The test series were carried out with six trichomonas strains and the following antivitamins: aminopterine, acetylpyridine, pyridine sulfonic acid, aminobutyric acid, pantoyltaurin, benzimidazol, 5.6-dimethyl-benzimidazid, azaadenin, avidine, phthiocol, dicumarol, tri-o-cresylphosphate, di-o-cresylacetate. Growth of trichomonas in the experiments with aminopterine, tri-o-cresylphosphate and di-o-cresylacetate was within the range of the control cultures. Similar were the results obtained with azaadenine and avidine, aminobutyric acid and pantoyltaurine. An inhibiting effect as a function of the concentration series was noticed with acetylpyridine and pyridine sulfonic acid. Tests with benzimidazole and 5.6-dimethyl-benzimidazole resulted in a trichomonastatic effect from concentrations above 0.80 mg/ml. A clear inhibiting effect upon the development of trichomonas cultures was seen with phthiocole at a concentration of 0.80 mg/ml. Considerably weaker was the inhibiting action of the series with the addition of dicumarol. (Modified author abstract)

Descriptors :   (*PROTOZOA, REPRODUCTIVE SYSTEM), (*ANTIMETABOLITES, PROTOZOA), METABOLISM, GROWTH(PHYSIOLOGY), PARASITES, WEST GERMANY

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE