Accession Number : AD0768941

Title :   Einfluss von Carcinogenen Nitrosaminen auf die Induktion der Serin-Dehydratase in der Rattenleber (The Influence of Carcinogenice Nitrosamines on the Induction of Serine Dehydratase in the Rat Liver),

Corporate Author : ROBERT KOCH-INSTITUT BERLIN (WEST GERMANY)

Personal Author(s) : Jennissen,H. ; Hoshino,J. ; Kroeger,H.

Report Date : 07 DEC 1970

Pagination or Media Count : 8

Abstract : Nitrosamine-associated carcinogensis disturbs the regulatory systems for various enzymes in the liver of rats. In the present paper, the influences of N-nitroso morpholine and diethyl-nitrosamine on the induction of serine dehydratase by casein hydrolysate and fasting were studied. Induction by casein remains unaffected by these two substances. Under diethyl-nitrosamine diet, induction by fasting is considerably increased, whereas N-nitroso morpholine shows no effect. By using glucose it was established, that the increased enzyme activity subsequent to induction by fasting is a consequence of an increased enzyme synthesis. (Author)

Descriptors :   (*NITROSO COMPOUNDS, *CANCER), (*ENZYMES, NITROSO COMPOUNDS), AMINES, LIVER, RATS, WEST GERMANY

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE