Accession Number : AD0769128

Title :   The Calcium-Dependent Stimulation of Thymic Lymphoblast DNA Synthesis and Proliferation by a Low Concentration of Cortisol,

Corporate Author : NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGICAL SCIENCES

Personal Author(s) : Whitfield,J. F. ; MacManus,J. P. ; Gillan,D. J.

Report Date : 20 FEB 1973

Pagination or Media Count : 8

Abstract : A low cortisol concentration (10 to minus 9th power M) induces the actively 'cycling' lymphoblasts in isolated thymic lymphocyte populations (suspended in a serum-free medium) to start synthesizing DNA, and these stimulated cells are able to progress into mitosis. However, a higher concentration (5 x 10 to minus 7th power M) of the steroid neither stimulates nor markedly reduces the lymphoblasts' DNA synthesis or proliferation. Cortisol's stimulatory action is a calcium-dependent process since 10 to minus 9th power M cortisol does not affect DNA synthesis and cell proliferation in thymocyte populations-suspended in calcium-free medium. (Author)

Descriptors :   (*Lymphocytes, Deoxyribonucleic acids), (*Deoxyribonucleic acids, Biosynthesis), (*Steroids, Lymphocytes), Leukocytes, Calcium, Stimulation(Physiology), Mitosis, Thymus, Cells(Biology), Canada

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE