Accession Number : AD0769505

Title :   The Synthesis of Substituted Aminoguanidines as Potential Anticarcinogenic Agents,

Corporate Author : NAVAL ACADEMY ANNAPOLIS MD

Personal Author(s) : Elliott,Richard A.

Report Date : 21 MAY 1973

Pagination or Media Count : 72

Abstract : The purpose of this project was to prepare cancer, chemotherapeutic, agents. Interest was focused on the guanindine structure, and various nitro- and nitroso- derivatives of 1-Methyl-1-nitroso-3-nitroguanidine were either prepared or attempted. Attempts were made, with limited success, at preparing derivatives of the following compound: Methyl GAG. A general description of the cancer problem has been made, as well as a brief presentation on the field of chemotherapy. A discussion of experimental methods employed, problems encountered, and results achieved has been presented. (Modified author abstract)

Descriptors :   (*Guanidines, Synthesis(Chemistry)), (*Nitroguanidine, Synthesis(Chemistry)), Molecular structure, Nitroso compounds, Cancer, Chemotherapeutic agents, Chemical reactions

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE