Accession Number : AD0769623

Title :   A Statistical Analysis of Indicator-Dillution Curves and an Application to the Real Time Analysis of Dye-Dilution Curves During Cardiac Surgery.

Descriptive Note : Research rept.,


Personal Author(s) : Frome,Edward L. ; Frederickson,Evan L.

Report Date : SEP 1973

Pagination or Media Count : 25

Abstract : Circulatory indicator-dilution curves are used to estimate blood flow and volume, and in certain situations the three-parameter lognormal density function can be employed to represent the first passage time distribution of tracer particles through the system. In this paper the least squares principle is used to develop a procedure for estimating the parameters in the lognormal model. A nonlinear regression program (which computes the least squares estimates) and a graphical estimation technique (that provides starting values) are described. An application of the least squares estimation procedure to the real time analysis of dye-dilution curves--obtained from patients during open-heart surgery--is presented, and an illustrative example is included. (Author)

Descriptors :   (*Heart function tests, Dyes), (*Blood circulation, Monitors), Statistical analysis, Regression analysis, Real time, Surgery, Heart, Physiology

Subject Categories : Medicine and Medical Research
      Statistics and Probability

Distribution Statement : APPROVED FOR PUBLIC RELEASE