Accession Number : AD0770471

Title :   Allergenic Effect of Florimycin,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Paustovskaya,V. V. ; Krasnokutskaya,L. M. ; Rappoport,M. B. ; Karpenko,V. N.

Report Date : 08 NOV 1973

Pagination or Media Count : 10

Abstract : In view of the fact that the Soviet medical industry is accelerating the production of florimycin and the prospect of its broad application is increasing, a need arose for an extensive study of this antibiotic and what effect it has on warm-blooded animals. More and more reports are encountered in the Soviet and foreign literature on the side effect the florimycin has on patients who received this preparation for therapeutic reasons and also on the experimental animals. This side effect is manifested as a toxic effect; furthermore, the most pronounced changes are observed in the liver and kidneys. The function of the vestibular apparatus is disrupted and the blood pressure is decreased.

Descriptors :   *Antibiotics, *Toxicity, *Allergic diseases, Blood pressure, Kidneys, Liver, USSR, Translations, Laboratory animals, Bioassay

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE