Accession Number : AD0770903

Title :   The Antiviral Action of Ribonuclease,

Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s) : Ershov,F. I. ; Urbakh,V. Yu.

Report Date : 1973

Pagination or Media Count : 11

Abstract : With the use of a model of the virus of Venezuelan equine encephalomyelitis, the inhibiting effect of a preparation of pancreatic ribonuclease on the accumulation and infectious and hemagglutinating activity of the virus, and interferon production in chicken embryo fibroblast culture were determined. Statistical processing confirmed a high degree of correlation in the suppression of all three types of activity. The mechanism of virus-inhibiting action of ribonuclease is discussed. The article includes two tables, two illustrations and a bibliography of 16 titles. (Author)

Descriptors :   *Antiviral agents, *Ribonuclease, *Interferon, Viruses, Venezuelan equine encephalomyelitis virus, Nuclease, Enzymes, USSR, Translations

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE